The self-titled first season of the anime is a derivative of the light novel’s first three volumes. Slayers NEXT was adapted from the events of volumes 4-8, whereas Slayers TRY is an original story. A fourth season, Slayers AGAIN, was rumored following the success of TRY, but early scheduling conflicts caused interest in the project to dissipate. A fourth anime series, Slayers Revolution, premiered in Japan on July 2, 2008. Megumi Hayashibara performed both the opening and ending theme songs. The new plot is told across two 13-episode arcs and follows an original storyline that has subplots based on events in the novels, with series director Takashi Watanabe and production studio J.C.Staff reprising their duties from the three original TV series. A fifth Slayers series titled Slayers Evolution-R is the second 13-episode arc of Slayers Revolution and was aired on AT-X starting on January 12, 2009 in Japan.
- The first OVA series, Slayers Special, consists of three individual episodes directed by Hiroshi Watanabe. The first episode was released in Japan on July 25, 1996 by Kadokowa Shoten and J.C.Staff, approximately 10 months following broadcast of the final episode of the original anime series.
- A second three-episode OVA series, Slayers Excellent followed in 1998, also directed by Wantabe and produced by J.C.Staff.
- Slayers The Motion Picture, also known as Slayers Perfect (or Slayers the Movie: Perfect Edition) and originally released in Japan simply as Slayers, is a 1995 film written by Kazuo Yamazaki, based on an original story by Hajime Kanzaka, and directed by Yamazaki and Hiroshi Watanabe.
- Slayers Return, also known as Slayers Movie 2 – The Return, is a 1996 film written by Kanzaka and directed by Kunihiko Yuyama and Hiroshi Watanabe.
- Slayers Great is a 1997 film written by Kanzaka and directed by Kunihiko Yuyama, Hiroshi Watanabe and Yoshimatsu Takahiro.
- Slayers Gorgeous is a 1998 film written by Kanzaka and directed by Hiroshi Watanabe.
- Slayers Premium is a 2001 short film written and directed by Junichi Satō.
All films were produced by J.C.Staff and licensed for home video release in North America by ADV Films. Slayers Return was adapted into a manga version.