The first adaptation of Saiyuki was a two episode OVA by Tokyo Kids. The first episode was released on April 23, 1999, while the second episode was released on August 27, 1999. A television series was created by Studio Pierrot and Dentsu entitled Gensomaden Saiyuki. The series aired on TV Tokyo from April 4, 2000 to March 27, 2001 on Tuesdays at 18:30, spanning 50 episodes. Another series, Saiyuki Reload was created by the same companies and it adapts from the manga of the same name. It aired on the same network from October 2, 2003 to March 25, 2004 on Thursdays at 18:30. A sequel titled Saiyuki Reload Gunlock was also created by the companies and aired on the same network from April 1, 2004 to September 23, 2004 on Thursdays at 25:30. ADV Films licensed Gensomaden Saiyuki and the movie. The sequels Saiyuki Reload and Saiyuki Reload Gunlock are licensed by Geneon in North America, and consist of 25 and 26 episodes respectively. Saiyuki Reload is faithful to the manga from the fourteenth episode and onward, having deviated from it for the first 13 episodes. Saiyuki Reload Gunlock also starts off deviated from the manga, until midway into the series, but strays from it during its finale. An anime television series adaptation of the Saiyuki Reload Blast manga series will premiere July 5, 2017 on Tokyo MX, TV Aichi, BS11, Sun TV. It will run for 12 episodes. Crunchyroll will be streaming the anime. Funimation will stream an English dub of the series.
Enoki Films holds the US license to Gensomaden Saiyuki under the title Saiyuki: Paradise Raiders. There has also been a movie (Saiyuki: Requiem) adapted into English that is also licensed by ADV. A new OVA has been released by Studio Pierrot, which covers the “Burial” arc of the Saiyuki Reload manga; it is called Saiyuki Reload: Burial.