The series was first adapted into a 20-minute anime OVA, released August 6, 2002. Later, it was also adapted into a 26-episode anime television series. Both were produced by Ashi Productions and Animax. The anime series premiered on May 20, 2003 in Japan on Animax, and was later licensed for Region 1 distribution by Geneon Entertainment. The Ultra Maniac series was produced by the anime television network, Animax, who have broadcast the series exclusively across Japan, East Asia, Southeast Asia, South Asia, and other regions, dubbing and broadcasting the series into English and other languages. It has been licensed for North American distribution by Geneon Entertainment, who have released the series across the region via a 7-volume DVD release, the first of which was released on April 4, 2005 and the last of which was released on April 18, 2006.
The anime adaptation has a very different plot starting after Ayu and Nina have first met. Instead of coming as a witch failure who is trying to prove herself to be more than she is said to be, Nina has come to Earth to find the five “Holy Stones”. She tells Ayu that whoever collects all five will qualify to marry the prince of the Magic Kingdom. Nina’s childhood friend Maya is also on Earth from the start, competing with Nina to find the stones. Though Nina does collect them all first, she learns that the prince and Maya are truly in love with one another, so Nina gives up the stones and her dream, allowing Maya and the prince to be with one another, and Nina stays on Earth with her friends.