A 26-episode anime adaptation produced by J.C.Staff aired between April and September 2010.
The October 2009 issue of LaLa announced that a 26 episode anime television adaptation of the series would be produced. It was broadcast in TBS and BS-TBS during Spring 2010. The April 2010 issue of LaLa revealed the broadcast date to be on April 1, 2010 at 1:55 midnight. The adaptation was also present at the Tokyo International Anime Fair with Ayumi Fujimura, Nobuhiko Okamoto, Kana Hanazawa and Yū Kobayashi’s attendance. The anime series is licensed by Sentai Filmworks, with The Anime Network currently streaming the series on their video portal. Anime distributor Section23 Films released the first subtitled-only set on DVD, June 7, 2011. The second subtitled-DVD set was released on August 2, 2011 A complete collection on DVD was released on October 9, 2012. Sentai Filmworks & Section23 will re-release the series on DVD and Blu-ray, with an English dub on January 27, 2015.
The staff list was announced and Hiroaki Sakurai directed the series with series composition done by Mamiko Ikeda who previously worked on the series composition for Emma: A Victorian Romance series and most recently the Rental Magica series and Hanasakeru Seishōnen, while the animation character designs by Yuki Imoto and music composed by Tōru Motoyama. The series was animated by J.C.Staff who previously worked on Honey and Clover, Toradora! and Nodame Cantabile. Ayumi Fujimura and Nobuhiko Okamoto took on the role of Misaki Ayuzawa and Takumi Usui respectively.
- The titular character of the story, 16-year-old Misaki Ayuzawa is the first female student council president at Seika High. She is known for her extremely bossy and strict attitude towards boys, and relentless attempts to reform them to live up to what she considers are acceptable standards of behavior. Though many of the male students fear and hate her, the ones who get to know her come to see that she is actually very fair and willing to help anyone who needs it.
- She eventually becomes widely respected for her good grades, her great athletic skill, and her many accomplishments as president. Her negative attitude towards males is mostly attributed to her father amassing a huge debt and then disappearing. Misaki became determined to make sure her sickly and helpless mother, Minako would not have to work so hard to support both Misaki and her younger sister, Suzuna. After her father left, she studied hard and learned martial arts and became Seika’s president. To this extent, she secretly, and at first reluctantly, works as a maid-waitress at Café Maid Latte. Misaki is always driven to do her best regardless of the endeavor, and has a strong sense of justice, though she also has a tendency to be too selfless for her own good.
- At Café Maid Latte, Misaki is called “Misa-chan” by her coworkers and customers. Misaki was shown being the most passionate with her job when she was dressed as a male and appealing to woman, saying she would like a guy like herself.
- Despite her initial annoyance towards Usui and her belief that his interest in her stems from being the only one who knows she works as a maid-waitress, she is in love with him. However, Misaki always denies her feelings for him and becomes awkward whenever a potentially intimate moment arises between them. In chapter 57, she eventually confesses her feelings for him and they become a couple, though secretly at Misaki’s insistence to preserve her reputation as the student council president. When Usui reveals that he is to transfer to Miyabigaoka, she openly reveals their relationship to the students at Seika High, despite the potential damage it may cause to her appearance. When told that Usui would be going to England, Misaki is shocked but keeps her composure and openly accepts his choice. After Usui stops texting her from England she seeks the help of the Miyabigaoka High School President, Tora Igarashi, for a way to travel to him. The deal between the two is for Misaki to travel to see Usui, but in return she must tell Usui to not cut all ties between himself and the Walker Family; benefiting Igarashi in him being in contact of a person of noble blood such as Usui. Usui and Misaki reunite in England and return home to Japan to finish out their high school years. In chapter 81, Misaki and Usui get engaged, and in chapter 85, Misaki becomes a diplomat/lawyer while Usui becomes a respected doctor and they get married.
- The most popular male student in Seika High, Takumi Usui is a 17-year-old boy who appears to take little interest in anything and prefers to observe things as they unfold. He has blond hair, which he inherited from his mother, and is extremely handsome, so much that even a few boys at Seika High are infatuated with him solely because of that. He also inexplicably wears glasses only at home. Usui proves to be extraordinarily talented in a number of different fields, including cooking, the violin, chess, martial arts and table etiquette. He also gets excellent grades and is an excellent athlete. However, he reveals very few details about his past willingly. He has taken an interest in Misaki because she stands from everyone else and her hard work makes her unique. He expresses his feelings mainly by teasing her and passing perverted comments to see her funny expressions, and she nicknames him “perverted outer-space alien” as a running gag in the series is Misaki wondering whether Usui is even human when he comes out relatively unscathed from a fall that would mortally injure someone on spot. Usui was also the first Seika student to discover Misaki’s maid secret and even though he is concerned about her risky work habits, she brushes it off as him wanting to blackmail her. As he has been in love with Misaki since the first time they met, he dislikes it and becomes jealous, though he has trouble expressing it, whenever other boys get her attention, including Shintani and Tora.
- At Misaki’s insistence, Usui reveals that he is an illegitimate child. His mother, a Japanese-English woman from the wealthy Walker family, had an affair with an unknown Japanese man (later revealed to be a butler of the Walker family); his mother died in childbirth. To conceal his origins, his maternal English grandfather sent Usui to live with his mother’s Japanese grandmother’s family, resulting in little contact with his older half-brother. Adopted by his mother’s cousin, Usui’s education was primarily through tutors, partially explaining his academic excellence (as shown when he checkmates the vice president of the Miyabigaoka high school chess club in very few moves). However, he became bored of the isolation and randomly selected a standard high school to attend; after enrolling in Seika High, he moved into a high-rise condo where he lives alone. During his first year at Seika, he quickly became popular among the girls, but not being interested in them, he systematically rejected them whenever they confessed to him, thus earning Misaki’s resentment of him. Within his class, even his classmates respect him and he is called “Usui-san”.
- In chapter 32, Usui confesses to Misaki during the school’s firework festival and they share a kiss, though the relationship does not become formalized until Misaki herself confesses her love to him in chapter 57. He is forced to transfer to Miyabigaoka High School for his third year of high school., though he still makes an effort to go out of his way to see Misaki every day. When in England, Usui texts Misaki every day and continues to tease her, such as by asking for the color of her underwear, until his brother takes his phone away. The event triggers Misaki’s deal with Tora Igarashi so she could go to England and meet with Usui, while Usui himself struggles in his confinement by his brother and maternal grandfather, the latter of whom still disowns him for being an illegitimate child. He eventually reunites with Misaki and reveals their relationship in front of the nobility. Usui is allowed to head back to Japan only if he agrees to keep his relations with the Walker family. Despite never attaining his grandfather’s approval, Usui is wed to Misaki in chapter 85 and becomes a doctor for his family.
Yuki Ochimura ni Ojou-sama!, a crossover between Kaichou wa Maid-Sama! and Yuki wa Jigoku ni Ochiru no Ka released by the Hiro Fujiwara in 2016 is set 12 years after the marriage & it is revealed that Usui & Misaki have a 10-year-old daughter called Sara and an 8-year-old son called Rui.